CATH Domain 2hvxA02

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Serine protease 37

3.4.21.39

Chymase.

based on mapping to UniProt P23946

Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.

-!- In mast cell granules. -!- Belongs to peptidase family S1.

CMA1_HUMAN

Homo sapiens

Chymase

PDB	2HVX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. Greco, M.N., Hawkins, M.J., Powell, E.T., Almond, H.R., de Garavilla, L., Hall, J., Minor, L.K., Wang, Y., Corcoran, T.W., Di Cera, E., Cantwell, A.M., Savvides, S.N., Damiano, B.P., Maryanoff, B.E. J.Med.Chem.