CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.30 | SH3 type barrels. |
|
2.30.30.280 | Adenine nucleotide alpha hydrolases-like domains |
Domain Context
CATH Clusters
| Superfamily | Adenine nucleotide alpha hydrolases-like domains |
| Functional Family | tRNA-specific 2-thiouridylase MnmA |
Enzyme Information
| 2.8.1.13 |
tRNA-uridine 2-sulfurtransferase.
based on mapping to UniProt Q97T38
A [protein]-S-sulfanyl-L-cysteine + uridine(34) in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 2-thiouridine(34) in tRNA + AMP + diphosphate + acceptor.
-!- The enzyme, found in bacteria, catalyzes formation of the 2-thiouridine modification in the wobble position of tRNA(Gln), tRNA(Lys) and tRNA(Glu).
|
UniProtKB Entries (1)
| Q97T38 |
MNMA_STRPN
Streptococcus pneumoniae TIGR4
TRNA-specific 2-thiouridylase MnmA
|
PDB Structure
| PDB | 2HMA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The Crystal Structure of tRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase TrmU from
Streptococcus pneumoniae
To be Published
|