1 keywords

CATH Domain 2hfpA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.565 Retinoid X Receptor
Homologous Superfamily 1.10.565.10 Retinoid X Receptor

Domain Context

CATH Clusters

Superfamily Retinoid X Receptor
Functional Family Peroxisome proliferator-activated receptor gamma

Enzyme Information

UniProtKB Entries (1)

P37231
PPARG_HUMAN
Homo sapiens
Peroxisome proliferator-activated receptor gamma

PDB Structure

PDB 2HFP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
Hopkins, C.R., O'neil, S.V., Laufersweiler, M.C., Wang, Y., Pokross, M., Mekel, M., Evdokimov, A., Walter, R., Kontoyianni, M., Petrey, M.E., Sabatakos, G., Roesgen, J.T., Richardson, E., Demuth Jr., T.P.
Bioorg.Med.Chem.Lett.