CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1970 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1970 |
| Functional Family | Probable multifunctional protein ADE2 |
Enzyme Information
| 4.1.1.21 |
Phosphoribosylaminoimidazole carboxylase.
based on mapping to UniProt P22234
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1- (5-phospho-D-ribosyl)imidazole + CO(2).
-!- While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18. -!- 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
|
| 6.3.2.6 |
Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
based on mapping to UniProt P22234
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate.
-!- Forms part of the purine biosynthesis pathway.
|
UniProtKB Entries (1)
| P22234 |
PUR6_HUMAN
Homo sapiens
Multifunctional protein ADE2
|
PDB Structure
| PDB | 2H31 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis.
J.Mol.Biol.
|
