CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.170 | Beta Complex |
|
2.170.300 | Tie2 ligand-binding domain fold |
|
2.170.300.10 | Tie2 ligand-binding domain superfamily |
Domain Context
CATH Clusters
| Superfamily | Tie2 ligand-binding domain superfamily |
| Functional Family |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q02763
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| O15123 |
ANGP2_HUMAN
Homo sapiens
Angiopoietin-2
|
PDB Structure
| PDB | 2GY7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.
Nat.Struct.Mol.Biol.
|
