CATH Domain 2gdoA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O14757

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757

CHK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase Chk1

PDB Structure

PDB	2GDO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors. Ni, Z.J., Barsanti, P., Brammeier, N., Diebes, A., Poon, D.J., Ng, S., Pecchi, S., Pfister, K., Renhowe, P.A., Ramurthy, S., Wagman, A.S., Bussiere, D.E., Le, V., Zhou, Y., Jansen, J.M., Ma, S., Gesner, T.G. Bioorg.Med.Chem.Lett.