1 keywords

CATH Domain 2g24B02

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 2G24
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring
Holsworth, D.D., Cai, C., Cheng, X.M., Cody, W.L., Downing, D.M., Erasga, N., Lee, C., Powell, N.A., Ednunds, J.J., Stier, M., Jalaie, M., Zhang, E., McConnell, P., Ryan, M.J., Bryant, J., Li, T., Kasani, A., Hall, E., Subedi, R., Rahim, M., Maiti, S.
BIOORG.MED.CHEM.LETT.