CATH Domain 2ftuA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.81	Receptor-associated Protein
	1.20.81.10	RAP domain

Domain Context

CATH Clusters

Superfamily	RAP domain
Functional Family	Alpha-2-macroglobulin receptor-associated protein

Enzyme Information

UniProtKB Entries (1)

AMRP_HUMAN

Homo sapiens

Alpha-2-macroglobulin receptor-associated protein

PDB Structure

PDB	2FTU
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. Lee, D., Walsh, J.D., Mikhailenko, I., Yu, P., Migliorini, M., Wu, Y., Krueger, S., Curtis, J.E., Harris, B., Lockett, S., Blacklow, S.C., Strickland, D.K., Wang, Y.X. Mol.Cell