CATH Domain 2fjkC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

4.1.2.13

Fructose-bisphosphate aldolase.

based on mapping to UniProt Q703I2

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

Q703I2

ALF_THECA

Thermus caldophilus

Fructose-bisphosphate aldolase

PDB Structure

PDB	2FJK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Stereoselectivity of fructose-1,6-bisphosphate aldolase in Thermus caldophilus Lee, J.H., Bae, J., Kim, D., Choi, Y., Im, Y.J., Koh, S., Kim, J.S., Kim, M.-K., Kang, G.B., Hong, S.-I., Lee, D.-S., Eom, S.H. Biochem.Biophys.Res.Commun.

Network disruptions