CATH Domain 2fbxA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Werner syndrome ATP-dependent helicase homolog

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt Q14191

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

3.1.-.-

Acting on ester bonds.

based on mapping to UniProt Q14191

UniProtKB Entries (1)

Q14191

WRN_HUMAN

Homo sapiens

Werner syndrome ATP-dependent helicase

PDB Structure

PDB	2FBX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Perry, J.J., Yannone, S.M., Holden, L.G., Hitomi, C., Asaithamby, A., Han, S., Cooper, P.K., Chen, D.J., Tainer, J.A. Nat.Struct.Mol.Biol.