CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.20 | Single Sheet | |
2.20.70 | Ubiquitin Ligase Nedd4; Chain: W; | |
2.20.70.10 |
Domain Context
CATH Clusters
Superfamily | 2.20.70.10 |
Functional Family | E3 ubiquitin-protein ligase |
Enzyme Information
2.3.2.26 |
HECT-type E3 ubiquitin transferase.
based on mapping to UniProt Q9HAU4
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. -!- In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein. -!- Cf. EC 2.3.2.27 and EC 2.3.2.31.
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UniProtKB Entries (1)
O15105 |
SMAD7_HUMAN
Homo sapiens
Mothers against decapentaplegic homolog 7
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PDB Structure
PDB | 2DJY |
External Links | |
Method | SOLUTION NMR |
Organism | Escherichia |
Primary Citation |
An Expanded WW Domain Recognition Motif Revealed by the Interaction between Smad7 and the E3 Ubiquitin Ligase Smurf2.
J.Biol.Chem.
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