CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.30 | SH3 type barrels. |
|
2.30.30.40 | SH3 Domains |
Domain Context
CATH Clusters
| Superfamily | SH3 Domains |
| Functional Family | Alpha-(1,6)-fucosyltransferase |
Enzyme Information
| 2.4.1.68 |
Glycoprotein 6-alpha-L-fucosyltransferase.
based on mapping to UniProt Q9BYC5
GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D- mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl- (1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N- acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D- glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D- glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta- D-glucosaminyl)asparagine.
-!- Catalyzes a reaction similar to that of EC 2.4.1.214, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,6- linkage rather than an alpha-1,3-linkage.
|
UniProtKB Entries (1)
| Q9BYC5 |
FUT8_HUMAN
Homo sapiens
Alpha-(1,6)-fucosyltransferase
|
PDB Structure
| PDB | 2DE0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Crystal structure of mammalian {alpha}1,6-fucosyltransferase, FUT8
Glycobiology
|
