CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family MER proto-oncogene, tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q12866
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q12866
MERTK_HUMAN
Homo sapiens
Tyrosine-protein kinase Mer

PDB Structure

PDB 2DBJ
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structures of the fn3 domain of human Proto-oncogene tyrosine-protein kinase MER precursor
Sato, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S.
To be Published
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