1 keywords

CATH Domain 2coiA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.470 D-amino Acid Aminotransferase; Chain A, domain 1
Homologous Superfamily 3.30.470.10 Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily 3.30.470.10
Functional Family Branched-chain-amino-acid aminotransferase

Enzyme Information

2.6.1.42
Branched-chain-amino-acid transaminase.
based on mapping to UniProt P54687
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

UniProtKB Entries (1)

P54687
BCAT1_HUMAN
Homo sapiens
Branched-chain-amino-acid aminotransferase, cytosolic

PDB Structure

PDB 2COI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
Goto, M., Miyahara, I., Hirotsu, K., Conway, M., Yennawar, N., Islam, M.M., Hutson, S.M.
J.Biol.Chem.