CATH Classification

Domain Context

CATH Clusters

Superfamily NADP-dependent oxidoreductase domain
Functional Family Aldo-keto reductase family 1 member A1

Enzyme Information

1.1.1.54
Allyl-alcohol dehydrogenase.
based on mapping to UniProt P14550
Allyl alcohol + NADP(+) = acrolein + NADPH.
-!- Also acts on saturated primary alcohols.
1.1.1.372
D/L-glyceraldehyde reductase.
based on mapping to UniProt P14550
(1) Glycerol + NADP(+) = L-glyceraldehyde + NADPH. (2) Glycerol + NADP(+) = D-glyceraldehyde + NADPH.
-!- The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). -!- It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. -!- The reaction is only observed in the direction of glyceraldehyde reduction.
1.1.1.20
Glucuronolactone reductase.
based on mapping to UniProt P14550
L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + NADPH.
1.1.1.19
Glucuronate reductase.
based on mapping to UniProt P14550
L-gulonate + NADP(+) = D-glucuronate + NADPH.
-!- Also reduces D-galacturonate. -!- May be identical with EC 1.1.1.2.
1.1.1.2
Alcohol dehydrogenase (NADP(+)).
based on mapping to UniProt P14550
An alcohol + NADP(+) = an aldehyde + NADPH.
-!- Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. -!- May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55. -!- Re-specific with respect to NADPH.

UniProtKB Entries (1)

P14550
AK1A1_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member A1

PDB Structure

PDB 2ALR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
El-Kabbani, O., Green, N.C., Lin, G., Carson, M., Narayana, S.V., Moore, K.M., Flynn, T.G., DeLucas, L.J.
Acta Crystallogr.,Sect.D