CATH Domain 1zebA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.720	Alkaline Phosphatase, subunit A
	3.40.720.10	Alkaline Phosphatase, subunit A

Domain Context

CATH Clusters

Superfamily	Alkaline Phosphatase, subunit A
Functional Family	Alkaline phosphatase

Enzyme Information

3.1.3.1

Alkaline phosphatase.

based on mapping to UniProt P05187

A phosphate monoester + H(2)O = an alcohol + phosphate.

-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P05187

PPB1_HUMAN

Homo sapiens

Alkaline phosphatase, placental type

PDB Structure

PDB	1ZEB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands. Llinas, P., Stura, E.A., Menez, A., Kiss, Z., Stigbrand, T., Millan, J.L., Le Du, M.H. J.Mol.Biol.