CATH Domain 1zcnA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family	Peptidyl-prolyl cis-trans isomerase Pin1

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q13526

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13526

PIN1_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PDB Structure

PDB	1ZCN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure-function-folding relationship in a WW domain. Jager, M., Zhang, Y., Bieschke, J., Nguyen, H., Dendel, G., Bowman, M.E., Noel, J.P., Gruebele, M., Kelly, J.W. Proc.Natl.Acad.Sci.Usa