CATH Domain 1z9iA01

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.1140	membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor like fold
	4.10.1140.10	membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor like domain

Domain Context

CATH Clusters

Superfamily	membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor like domain
Functional Family	Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P00533

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533

EGFR_HUMAN

Homo sapiens

Epidermal growth factor receptor

PDB Structure

PDB	1Z9I
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	A Structural Model for the Membrane-bound Form of the Juxtamembrane Domain of the Epidermal Growth Factor Receptor Choowongkomon, K., Carlin, C.R. J.Biol.Chem.