CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Hemagglutinin-neuraminidase

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P04850
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P04850
HN_PIV5
Simian virus 5 (strain W3)
Hemagglutinin-neuraminidase

PDB Structure

PDB 1Z4Y
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.
Yuan, P., Thompson, T.B., Wurzburg, B.A., Paterson, R.G., Lamb, R.A., Jardetzky, T.S.
Structure