CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.175 | Diphtheria Toxin; domain 1 |
|
3.90.175.10 | Diphtheria Toxin, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Diphtheria Toxin, domain 1 |
| Functional Family | Diphtheria toxin |
Enzyme Information
| 2.4.2.36 |
NAD(+)--diphthamide ADP-ribosyltransferase.
based on mapping to UniProt P00588
NAD(+) + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2].
-!- Dihtheria toxin and some other bacterial toxins catalyze this reaction, which inactivates translation elongation factor 2 (EF2). -!- The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. -!- Cf. EC 2.4.2.31. -!- The relevant histidine of EF2 is His(715) in mammals, His(699) in yeast and His(600) in Pyrococcus horikoshii.
|
UniProtKB Entries (2)
| P00588 |
DTX_CORBE
Corynephage beta
Diphtheria toxin
|
| Q99075 |
HBEGF_HUMAN
Homo sapiens
Proheparin-binding EGF-like growth factor
|
PDB Structure
| PDB | 1XDT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor.
Mol.Cell
|
