CATH Domain 1wumA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Domain Context

CATH Clusters

Superfamily	Bromodomain-like
Functional Family	Histone acetyltransferase KAT2B

Enzyme Information

2.3.1.48	Histone acetyltransferase. based on mapping to UniProt Q92831 Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. -!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.
2.3.1.57	Diamine N-acetyltransferase. based on mapping to UniProt Q92831 Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. -!- Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)- acetylspermidine and N(8)-acetylspermidine.

UniProtKB Entries (1)

KAT2B_HUMAN

Homo sapiens

Histone acetyltransferase KAT2B

PDB Structure

PDB	1WUM
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Selective small molecules blocking HIV-1 Tat and coactivator PCAF association Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M. J.Am.Chem.Soc.