CATH Domain 1wr0A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.80	Phosphotransferase system, lactose/cellobiose-type IIA subunit

Domain Context

CATH Clusters

Superfamily	Phosphotransferase system, lactose/cellobiose-type IIA subunit
Functional Family	Vacuolar protein sorting-associated protein 4A

Enzyme Information

3.6.4.6

Vesicle-fusing ATPase.

based on mapping to UniProt O75351

ATP + H(2)O = ADP + phosphate.

-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

O75351

VPS4B_HUMAN

Homo sapiens

Vacuolar protein sorting-associated protein 4B

PDB Structure

PDB	1WR0
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Structural characterization of the MIT domain from human Vps4b Takasu, H., Jee, J.G., Ohno, A., Goda, N., Fujiwara, K., Tochio, H., Shirakawa, M., Hiroaki, H. Biochem.Biophys.Res.Commun.