CATH Domain 1wmaA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Carbonyl reductase [NADPH] 1

Enzyme Information

1.1.1.189	Prostaglandin-E(2) 9-reductase. based on mapping to UniProt P16152 (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. -!- Reduces prostaglandin E(2) to prostaglandin F(2)-alpha. -!- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. -!- May be identical with EC 1.1.1.197.
1.1.1.197	15-hydroxyprostaglandin dehydrogenase (NADP(+)). based on mapping to UniProt P16152 (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH. -!- Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196). -!- May be identical with EC 1.1.1.189.
1.1.1.184	Carbonyl reductase (NADPH). based on mapping to UniProt P16152 R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. -!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).

UniProtKB Entries (1)

CBR1_HUMAN

Homo sapiens

Carbonyl reductase [NADPH] 1

PDB Structure

PDB	1WMA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	An unbiased cell morphology-based screen for new, biologically active small molecules Tanaka, M., Bateman, R., Rauh, D., Vaisberg, E., Ramachandani, S., Zhang, C., Hansen, K.C., Burlingame, A.L., Trautman, J.K., Shokat, K.M., Adams, C.L. Plos Biol.