CATH Domain 1uv5A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Glycogen synthase kinase-3 beta

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P49841 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26	[Tau protein] kinase. based on mapping to UniProt P49841 ATP + [tau protein] = ADP + [tau protein] phosphate. -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

GSK3B_HUMAN

Homo sapiens

Glycogen synthase kinase-3 beta

PDB Structure

PDB	1UV5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Gsk-3-Selective Inhibitors Derived from Tyrian Purple Indurubins Meijer, L., Skaltsounis, A.-L., Magiatis, P., Polychronopoulous, P., Knockaert, M., Leost, M., Ryan, X.P., Vonica, C.A., Brivanlou, A., Dajani, R., Crovace, C., Tarricone, C., Musacchio, A., Roe, S.M., Pearl, L.H., Greengard, P. Chem.Biol.