CATH Domain 1ujxA01

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.200	Tumour Suppressor Smad4
	2.60.200.20

Domain Context

CATH Clusters

Superfamily	2.60.200.20
Functional Family	bifunctional polynucleotide phosphatase/kinase

Enzyme Information

2.7.1.78	Polynucleotide 5'-hydroxyl-kinase. based on mapping to UniProt Q9JLV6 ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. -!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.
3.1.3.32	Polynucleotide 3'-phosphatase. based on mapping to UniProt Q9JLV6 A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate. -!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.

UniProtKB Entries (1)

PNKP_MOUSE

Mus musculus

Bifunctional polynucleotide phosphatase/kinase

PDB Structure

PDB	1UJX
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The forkhead associated (FHA) domain like structure from mouse polynucleotide kinase 3'-phosphatase Tomizawa, T., Koshiba, S., Kigawa, T., Yokoyama, S. To be Published