CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
|
3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
| Superfamily | 3.40.47.10 |
| Functional Family | Chalcone synthase 1 |
Enzyme Information
| 2.3.1.233 |
1,3,6,8-tetrahydroxynaphthalene synthase.
based on mapping to UniProt Q9FCA7
5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO(2) + H(2)O.
-!- Isolated from the fungus Colletotrichum lagenarium, and the bacteria Streptomyces coelicolor and Streptomyces peucetius. -!- It only uses malonyl-CoA, without invovement of acetyl-CoA.
|
UniProtKB Entries (1)
| Q9FCA7 |
RPPA_STRCO
Streptomyces coelicolor A3(2)
1,3,6,8-tetrahydroxynaphthalene synthase
|
PDB Structure
| PDB | 1U0M |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates
J.Biol.Chem.
|