CATH Domain 1sl3A01

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P28504	HIR2_HIRME Hirudo medicinalis Hirudin-2

PDB	1SL3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors Young, M.B., Barrow, J.C., Glass, K.L., Lundell, G.F., Newton, C.L., Pellicore, J.M., Rittle, K.E., Selnick, H.G., Stauffer, K.J., Vacca, J.P., Williams, P.D., Bohn, D., Clayton, F.C., Cook, J.J., Krueger, J.A., Kuo, L.C., Lewis, S.D., Lucas, B.J., McMasters, D.R., Miller-Stein, C., Pietrak, B.L. J.Med.Chem.