CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1680 | ligand-binding face of the semaphorins, domain 2 |
|
3.30.1680.10 | ligand-binding face of the semaphorins, domain 2 |
Domain Context
CATH Clusters
| Superfamily | ligand-binding face of the semaphorins, domain 2 |
| Functional Family | Macrophage-stimulating 1 receptor b |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P08581 |
MET_HUMAN
Homo sapiens
Hepatocyte growth factor receptor
|
PDB Structure
| PDB | 1SHY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor.
Embo J.
|
