×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 1s3wA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.430 Dihydrofolate Reductase, subunit A
Homologous Superfamily 3.40.430.10 Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00374
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00374
DYR_HUMAN
Homo sapiens
Dihydrofolate reductase

PDB Structure

PDB 1S3W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.
Cody, V., Luft, J.R., Pangborn, W., Gangjee, A., Queener, S.F.
Acta Crystallogr.,Sect.D
CATH-Gene3D is a Global Biodata Core Resource Learn more...