CATH Domain 1q8lA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.100

Domain Context

CATH Clusters

Superfamily	3.30.70.100
Functional Family	ATPase copper transporting alpha

Enzyme Information

7.2.2.8

P-type Cu(+) transporter.

based on mapping to UniProt Q04656

ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2).

-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC 7.2.2.9, which mainly transports the divalent copper ion. -!- Formerly EC 3.6.3.54.

UniProtKB Entries (1)

Q04656

ATP7A_HUMAN

Homo sapiens

Copper-transporting ATPase 1

PDB Structure

PDB	1Q8L
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Structure and metal binding studies of the second copper binding domain of the Menkes ATPase. Jones, C.E., Daly, N.L., Cobine, P.A., Craik, D.J., Dameron, C.T. J.Struct.Biol.