CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Malic enzyme |
Enzyme Information
| 1.1.1.38 |
Malate dehydrogenase (oxaloacetate-decarboxylating).
based on mapping to UniProt P23368
(1) (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. (2) Oxaloacetate = pyruvate + CO(2).
-!- Unlike EC 1.1.1.39, this enzyme can also decarboxylate oxaloacetate, cf. EC 1.1.1.40.
|
UniProtKB Entries (1)
| P23368 |
MAOM_HUMAN
Homo sapiens
NAD-dependent malic enzyme, mitochondrial
|
PDB Structure
| PDB | 1PJ2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure
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