CATH Domain 1pf7E00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1580	Nucleoside phosphorylase domain

Domain Context

CATH Clusters

Superfamily	Nucleoside phosphorylase domain
Functional Family

Enzyme Information

2.4.2.1

Purine-nucleoside phosphorylase.

based on mapping to UniProt P00491

(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.

-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.

UniProtKB Entries (1)

P00491

PNPH_HUMAN

Homo sapiens

Purine nucleoside phosphorylase

PDB Structure

PDB	1PF7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural basis for inhibition of human PNP by immucillin-H De Azevedo Jr., W.F., Canduri, F., Dos Santos, D.M., Pereira, J.H., Dias, M.V.B., Silva, R.G., Mendes, M.A., Palma, M.S., Basso, L.A., Santos, D.S. Biochem.Biophys.Res.Commun.