CATH Domain 1o2gH02

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P28504	HIR2_HIRME Hirudo medicinalis Hirudin-2

PDB	1O2G
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors Katz, B.A., Elrod, K., Verner, E., Mackman, R.L., Luong, C., Shrader, W.D., Sendzik, M., Spencer, J.R., Sprengeler, P.A., Kolesnikov, A., Tai, V.W.-F., Hui, H.C., Breitenbucher, J.G., Allen, D., Janc, J.W. J.Mol.Biol.