CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Pro-epidermal growth factor

Enzyme Information

UniProtKB Entries (1)

P00533
EGFR_HUMAN
Homo sapiens
Epidermal growth factor receptor

PDB Structure

PDB 1NQL
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
EGF activates its receptor by removing interactions that auto-inhibit ectodomain dimerization
Ferguson, K.M., Berger, M.B., Mendrola, J.M., Cho, H., Leahy, D.J., Lemmon, M.A.
Mol.Cell