CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Thymidylate kinase |
Enzyme Information
| 2.7.4.9 |
dTMP kinase.
based on mapping to UniProt P23919
ATP + dTMP = ADP + dTDP.
|
UniProtKB Entries (1)
| P23919 |
KTHY_HUMAN
Homo sapiens
Thymidylate kinase
|
PDB Structure
| PDB | 1NN1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of human thymidylate kinase in complex with prodrugs:
implications for the structure-based design of novel compounds
Biochemistry
|
