CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | Carboxylic ester hydrolase |
Enzyme Information
| 3.1.1.56 |
Methylumbelliferyl-acetate deacetylase.
based on mapping to UniProt P23141
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
-!- Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters.
|
| 3.1.1.1 |
Carboxylesterase.
based on mapping to UniProt P23141
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
-!- Wide specificity; also hydrolyzes vitamin A esters. -!- The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13. -!- Formerly EC 3.1.1.12.
|
UniProtKB Entries (1)
| P23141 |
EST1_HUMAN
Homo sapiens
Liver carboxylesterase 1
|
PDB Structure
| PDB | 1MX1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's
Drug Tacrine: From Binding Promiscuity to Selective Inhibition
CHEM.BIOL.
|
