CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.140 | Cytidine Deaminase; domain 2 |
|
3.40.140.10 | Cytidine Deaminase, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Cytidine Deaminase, domain 2 |
| Functional Family | Cytidine deaminase |
Enzyme Information
| 3.5.4.5 |
Cytidine deaminase.
based on mapping to UniProt P32320
(1) Cytidine + H(2)O = uridine + NH(3). (2) 2'-deoxycytidine + H(2)O = 2'-deoxyuridine + NH(3).
-!- Catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. -!- The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. -!- Formerly EC 3.5.4.14.
|
UniProtKB Entries (1)
| P32320 |
CDD_HUMAN
Homo sapiens
Cytidine deaminase
|
PDB Structure
| PDB | 1MQ0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of human cytidine deaminase bound to a potent inhibitor
J.Med.Chem.
|
