CATH Domain 1mi8A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.16	Endonuclease - Pi-scei; Chain A, domain 1
	2.170.16.10	Hedgehog/Intein (Hint) domain

Domain Context

CATH Clusters

Superfamily	Hedgehog/Intein (Hint) domain
Functional Family

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt Q55418

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q55418

DNAB_SYNY3

Synechocystis sp. PCC 6803 substr. Kazusa

Replicative DNA helicase

PDB Structure

PDB	1MI8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing Ding, Y., Xu, M.Q., Ghosh, I., Chen, X., Ferrandon, S., Lesage, G., Rao, Z. J.Biol.Chem.