CATH Domain 1mffC00

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.429	Macrophage Migration Inhibitory Factor
	3.30.429.10	Macrophage Migration Inhibitory Factor

Domain Context

CATH Clusters

Superfamily	Macrophage Migration Inhibitory Factor
Functional Family	Macrophage migration inhibitory factor

Enzyme Information

5.3.2.1	Phenylpyruvate tautomerase. based on mapping to UniProt P34884 Keto-phenylpyruvate = enol-phenylpyruvate. -!- Also acts on other arylpyruvates.
5.3.3.12	L-dopachrome isomerase. based on mapping to UniProt P34884 L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. -!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).

UniProtKB Entries (1)

MIF_MOUSE

Mus musculus

Macrophage migration inhibitory factor

PDB Structure

PDB	1MFF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants. Stamps, S.L., Taylor, A.B., Wang, S.C., Hackert, M.L., Whitman, C.P. Biochemistry