CATH Domain 1m27C00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.40	SH3 Domains

Domain Context

CATH Clusters

Superfamily	SH3 Domains
Functional Family	Tyrosine-protein kinase Fyn

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P06241

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q13291

SLAF1_HUMAN

Homo sapiens

Signaling lymphocytic activation molecule

PDB Structure

PDB	1M27
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	SAP couples Fyn to SLAM immune receptors. Chan, B., Lanyi, A., Song, H.K., Griesbach, J., Simarro-Grande, M., Poy, F., Howie, D., Sumegi, J., Terhorst, C., Eck, M.J. NAT.CELL BIOL.