CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | Collagenase 3 |
Enzyme Information
| 3.4.24.34 |
Neutrophil collagenase.
based on mapping to UniProt P22894
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
-!- Similar to interstitial collagenase in specificity. -!- Stored in the specific granules of neutrophil leukocytes. -!- Belongs to peptidase family M10B.
|
UniProtKB Entries (1)
| P22894 |
MMP8_HUMAN
Homo sapiens
Neutrophil collagenase
|
PDB Structure
| PDB | 1JAN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
FEBS Lett.
|
