CATH Classification
Domain Context
CATH Clusters
| Superfamily | 2.40.50.100 |
| Functional Family |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt Q8RQE8
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
| Q8RQE9 |
RPOB_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit beta
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PDB Structure
| PDB | 1IW7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
NATURE
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