CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.82 | ADP Ribosyl Cyclase; Chain A, domain 1 |
|
1.20.82.10 | ADP Ribosyl Cyclase; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | ADP Ribosyl Cyclase; Chain A, domain 1 |
| Functional Family | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
Enzyme Information
| 3.2.2.6 |
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
based on mapping to UniProt Q10588
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
-!- This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. -!- In addition, the enzyme also catalyzes EC 2.4.99.20. -!- It is also able to act on beta-nicotinamide D-ribonucleotide. -!- Cf. EC 3.2.2.5.
|
UniProtKB Entries (1)
| Q10588 |
BST1_HUMAN
Homo sapiens
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
|
PDB Structure
| PDB | 1ISH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Trichoplusia |
| Primary Citation |
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.
J.Mol.Biol.
|
