CATH Domain 1ijrA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	Tyrosine-protein kinase Lck

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P06239

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06239

LCK_HUMAN

Homo sapiens

Tyrosine-protein kinase Lck

PDB Structure

PDB	1IJR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Kawahata, N., Yang, M.G., Luke, G.P., Shakespeare, W.C., Sundaramoorthi, R., Wang, Y., Johnson, D., Merry, T., Violette, S., Guan, W., Bartlett, C., Smith, J., Hatada, M., Lu, X., Dalgarno, D.C., Eyermann, C.J., Bohacek, R.S., Sawyer, T.K. Bioorg.Med.Chem.Lett.