CATH Domain 1h1bB01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Neutrophil elastase

Enzyme Information

3.4.21.37

Leukocyte elastase.

based on mapping to UniProt P08246

Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.

-!- Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (1)

P08246

ELNE_HUMAN

Homo sapiens

Neutrophil elastase

PDB Structure

PDB	1H1B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151) Macdonald, S.J.F., Dowle, M.D., Harrison, L.A., Clarke, G.D.E., Inglis, G.G.A., Johnson, M.R., Shah, P., Smith, R.A., Amour, A., Fleetwood, G., Humphreys, D.C., Molloy, C.R., Dixon, M., Godward, R.E., Wonacott, A.J., Singh, O.M.P., Hodgson, S.T., Hardy, G.W. J.Med.Chem.