CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1280 | Alpha/beta knot |
|
3.40.1280.10 | SPOUT methyltransferase, trefoil knot domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.1280.10 |
| Functional Family | 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB |
Enzyme Information
| 2.1.1.185 |
23S rRNA (guanosine(2251)-2'-O)-methyltransferase.
based on mapping to UniProt P63177
S-adenosyl-L-methionine + guanosine(2251) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methylguanosine(2251) in 23S rRNA.
-!- The enzyme catalyzes the methylation of guanosine(2251), a modification conserved in the peptidyltransferase domain of 23S rRNA.
|
UniProtKB Entries (1)
| P63177 |
RLMB_ECOLI
Escherichia coli K-12
23S rRNA (guanosine-2'-O-)-methyltransferase RlmB
|
PDB Structure
| PDB | 1GZ0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Structure of the Rlmb 23S Rrna Methyltransferase Reveals a New Methyltransferase Fold with a Unique Knot
Structure
|
