CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.150 | C2 domain |
Domain Context
CATH Clusters
| Superfamily | C2 domain |
| Functional Family | Protein kinase C epsilon |
Enzyme Information
| 2.7.11.13 |
Protein kinase C.
based on mapping to UniProt P09216
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| P09216 |
KPCE_RAT
Rattus norvegicus
Protein kinase C epsilon type
|
PDB Structure
| PDB | 1GMI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the C2 Domain from Novel Protein Kinase Cepsilon. A Membrane Binding Model for Ca(2+ )-Independent C2 Domains
J.Mol.Biol.
|
