CATH Domain 1gmiA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.150	C2 domain

Domain Context

CATH Clusters

Superfamily	C2 domain
Functional Family	Protein kinase C epsilon

Enzyme Information

2.7.11.13

Protein kinase C.

based on mapping to UniProt P09216

ATP + a protein = ADP + a phosphoprotein.

-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P09216

KPCE_RAT

Rattus norvegicus

Protein kinase C epsilon type

PDB Structure

PDB	1GMI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the C2 Domain from Novel Protein Kinase Cepsilon. A Membrane Binding Model for Ca(2+ )-Independent C2 Domains Ochoa, W.F., Garcia-Garcia, J., Fita, I., Corbalan-Garcia, S., Verdaguer, N., Gomez-Fernandez, J.C. J.Mol.Biol.

Network disruptions