CATH Domain 1gi8B01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73

U-plasminogen activator.

based on mapping to UniProt P00749

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749

UROK_HUMAN

Homo sapiens

Urokinase-type plasminogen activator

PDB Structure

PDB	1GI8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Pichia
Primary Citation	A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. Katz, B.A., Elrod, K., Luong, C., Rice, M.J., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hataye, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W. J.Mol.Biol.