CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | KHG/KDPG aldolase |
Enzyme Information
| 4.1.3.16 |
4-hydroxy-2-oxoglutarate aldolase.
based on mapping to UniProt P0A955
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
-!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.
|
| 4.1.2.14 |
2-dehydro-3-deoxy-phosphogluconate aldolase.
based on mapping to UniProt P0A955
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.
|
UniProtKB Entries (1)
| P0A955 |
ALKH_ECOLI
Escherichia coli K-12
KHG/KDPG aldolase
|
PDB Structure
| PDB | 1FWR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
Structure
|
