CATH Classification
Domain Context
CATH Clusters
| Superfamily | Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A |
| Functional Family | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
Enzyme Information
| 2.4.1.101 |
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
based on mapping to UniProt P27115
UDP-N-acetyl-alpha-D-glucosamine + alpha-D-Man-(1->3)-[alpha-D-Man- (1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D- GlcNAc-(1->4)-alpha-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha- D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-N- Asn-[protein].
-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- Its action is required before the other N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II through VI) can act. -!- While the natural substrate (produced by EC 3.2.1.113) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man- (1->3)-beta-D-Man-R. -!- Formerly EC 2.4.1.51.
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UniProtKB Entries (1)
| P27115 |
MGAT1_RABIT
Oryctolagus cuniculus
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
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PDB Structure
| PDB | 1FO9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily.
EMBO J.
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